Effect of ultraviolet treatment on bacterial attachment and osteogenic activity to alkali-treated titanium with nanonetwork structures
Identifieur interne : 000268 ( Main/Exploration ); précédent : 000267; suivant : 000269Effect of ultraviolet treatment on bacterial attachment and osteogenic activity to alkali-treated titanium with nanonetwork structures
Auteurs : Honghao Zhang [Japon, République populaire de Chine] ; Satoshi Komasa [Japon] ; Chiho Mashimo ; Tohru Sekino [Japon] ; Joji Okazaki [Japon]Source :
- International Journal of Nanomedicine [ 1176-9114 ] ; 2017.
Abstract
Alkali-treated titanium with nanonetwork structures (TNS) possesses good osteogenic activity; however, the resistance of this material to bacterial contamination remains inadequate. As such, TNS implants are prone to postoperative infection. In this work, we attempted to alter the biological properties of TNS by treatment with short-duration high-intensity ultraviolet (UV) irradiation.
TNS discs were treated with UV light (wavelength =254 nm, strength =100 mW/cm2) for 15 minutes using a UV-irradiation machine. We carried out a surface characterization and evaluated the discs for bacterial film formation, protein adsorption, and osteogenic features.
The superhydrophilicity and surface hydrocarbon elimination exhibited by the treated material (UV-treated titanium with a nanonetwork structure [UV-TNS]) revealed that this treatment effectively changed the surface characteristics of TNS. Notably, UV-TNS also showed reduced colonization by
We suggest that simple UV treatment has great clinical potential for TNS implants, as it promotes the osseointegration of the TNS while reducing bacterial contamination, and can be conducted chair-side immediately prior to implantation.
Url:
DOI: 10.2147/IJN.S136273
PubMed: 28721040
PubMed Central: 5500560
Affiliations:
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Chine</country><wicri:regionArea>Department of Stomatology, Nanfang Hospital and College of Stomatology, Southern Medical University, Guangzhou, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Komasa, Satoshi" sort="Komasa, Satoshi" uniqKey="Komasa S" first="Satoshi" last="Komasa">Satoshi Komasa</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-12-4633">Department of Removable Prosthodontics and Occlusion, Osaka Dental University, Hirakata, Osaka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Removable Prosthodontics and Occlusion, Osaka Dental University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Mashimo, Chiho" sort="Mashimo, Chiho" uniqKey="Mashimo C" first="Chiho" last="Mashimo">Chiho Mashimo</name><affiliation><nlm:aff id="af3-ijn-12-4633">Department of Bacteriology, Osaka Dental University, Hirakata</nlm:aff><wicri:noCountry code="subfield">Hirakata</wicri:noCountry></affiliation></author><author><name sortKey="Sekino, Tohru" sort="Sekino, Tohru" uniqKey="Sekino T" first="Tohru" last="Sekino">Tohru Sekino</name><affiliation wicri:level="1"><nlm:aff id="af4-ijn-12-4633">The Institute of Scientific and Industrial Research, Osaka University, Suita, Osaka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>The Institute of Scientific and Industrial Research, Osaka University, Suita, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Okazaki, Joji" sort="Okazaki, Joji" uniqKey="Okazaki J" first="Joji" last="Okazaki">Joji Okazaki</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-12-4633">Department of Removable Prosthodontics and Occlusion, Osaka Dental University, Hirakata, Osaka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Removable Prosthodontics and 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type="wicri:Area/Ncbi/Checkpoint">007096</idno><idno type="wicri:doubleKey">1176-9114:2017:Zhang H:effect:of:ultraviolet</idno><idno type="wicri:Area/Main/Merge">000268</idno><idno type="wicri:Area/Main/Curation">000268</idno><idno type="wicri:Area/Main/Exploration">000268</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of ultraviolet treatment on bacterial attachment and osteogenic activity to alkali-treated titanium with nanonetwork structures</title><author><name sortKey="Zhang, Honghao" sort="Zhang, Honghao" uniqKey="Zhang H" first="Honghao" last="Zhang">Honghao Zhang</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-12-4633">Department of Removable Prosthodontics and Occlusion, Osaka Dental University, Hirakata, Osaka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Removable Prosthodontics and Occlusion, Osaka Dental University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-12-4633">Department of Stomatology, Nanfang Hospital and College of Stomatology, Southern Medical University, Guangzhou, Guangdong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Stomatology, Nanfang Hospital and College of Stomatology, Southern Medical University, Guangzhou, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Komasa, Satoshi" sort="Komasa, Satoshi" uniqKey="Komasa S" first="Satoshi" last="Komasa">Satoshi Komasa</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-12-4633">Department of Removable Prosthodontics and Occlusion, Osaka Dental University, Hirakata, Osaka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Removable Prosthodontics and Occlusion, Osaka Dental University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Mashimo, Chiho" sort="Mashimo, Chiho" uniqKey="Mashimo C" first="Chiho" last="Mashimo">Chiho Mashimo</name><affiliation><nlm:aff id="af3-ijn-12-4633">Department of Bacteriology, Osaka Dental University, Hirakata</nlm:aff><wicri:noCountry code="subfield">Hirakata</wicri:noCountry></affiliation></author><author><name sortKey="Sekino, Tohru" sort="Sekino, Tohru" uniqKey="Sekino T" first="Tohru" last="Sekino">Tohru Sekino</name><affiliation wicri:level="1"><nlm:aff id="af4-ijn-12-4633">The Institute of Scientific and Industrial Research, Osaka University, Suita, Osaka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>The Institute of Scientific and Industrial Research, Osaka University, Suita, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Okazaki, Joji" sort="Okazaki, Joji" uniqKey="Okazaki J" first="Joji" last="Okazaki">Joji Okazaki</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-12-4633">Department of Removable Prosthodontics and Occlusion, Osaka Dental University, Hirakata, Osaka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Removable Prosthodontics and Occlusion, Osaka Dental University, Hirakata, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Nanomedicine</title><idno type="ISSN">1176-9114</idno><idno type="eISSN">1178-2013</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>Alkali-treated titanium with nanonetwork structures (TNS) possesses good osteogenic activity; however, the resistance of this material to bacterial contamination remains inadequate. As such, TNS implants are prone to postoperative infection. In this work, we attempted to alter the biological properties of TNS by treatment with short-duration high-intensity ultraviolet (UV) irradiation.</p></sec><sec><title>Methods</title><p>TNS discs were treated with UV light (wavelength =254 nm, strength =100 mW/cm<sup>2</sup>) for 15 minutes using a UV-irradiation machine. We carried out a surface characterization and evaluated the discs for bacterial film formation, protein adsorption, and osteogenic features.</p></sec><sec><title>Results</title><p>The superhydrophilicity and surface hydrocarbon elimination exhibited by the treated material (UV-treated titanium with a nanonetwork structure [UV-TNS]) revealed that this treatment effectively changed the surface characteristics of TNS. Notably, UV-TNS also showed reduced colonization by <italic>Actinomyces oris</italic> during an initial attachment period and inhibition of biofilm formation for up to 6 hours. Moreover, compared to conventional TNS, UV-TNS showed superior osteogenic activity as indicated by increased levels of adhesion, proliferation, alkaline phosphatase activity, osteogenic factor production, and osteogenesis-related gene expression by rat bone marrow mesenchymal stem cells (rBMMSCs). This inverse relationship between bacterial attachment and cell adhesion could be due to the presence of electron–hole pairs induced by high-intensity UV treatment.</p></sec><sec><title>Conclusion</title><p>We suggest that simple UV treatment has great clinical potential for TNS implants, as it promotes the osseointegration of the TNS while reducing bacterial contamination, and can be conducted chair-side immediately prior to implantation.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Xuereb, M" uniqKey="Xuereb M">M Xuereb</name></author><author><name sortKey="Camilleri, J" uniqKey="Camilleri J">J Camilleri</name></author><author><name sortKey="Attard, Nj" uniqKey="Attard N">NJ Attard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buser, D" uniqKey="Buser D">D Buser</name></author><author><name sortKey="Janner, Sf" uniqKey="Janner S">SF Janner</name></author><author><name 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Kopf</name></author><author><name sortKey="Ruch, S" uniqKey="Ruch S">S Ruch</name></author><author><name sortKey="Berner, S" uniqKey="Berner S">S Berner</name></author><author><name sortKey="Spencer, Nd" uniqKey="Spencer N">ND Spencer</name></author><author><name sortKey="Maniura Weber, K" uniqKey="Maniura Weber K">K Maniura-Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kitajima, H" uniqKey="Kitajima H">H Kitajima</name></author><author><name sortKey="Ogawa, T" uniqKey="Ogawa T">T Ogawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Funato, A" uniqKey="Funato A">A Funato</name></author><author><name sortKey="Ogawa, T" uniqKey="Ogawa T">T Ogawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, S" uniqKey="Suzuki S">S Suzuki</name></author><author><name sortKey="Kobayashi, H" uniqKey="Kobayashi H">H Kobayashi</name></author><author><name sortKey="Ogawa, T" uniqKey="Ogawa T">T Ogawa</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Mashimo, Chiho" sort="Mashimo, Chiho" uniqKey="Mashimo C" first="Chiho" last="Mashimo">Chiho Mashimo</name></noCountry><country name="Japon"><noRegion><name sortKey="Zhang, Honghao" sort="Zhang, Honghao" uniqKey="Zhang H" first="Honghao" last="Zhang">Honghao Zhang</name></noRegion><name sortKey="Komasa, Satoshi" sort="Komasa, Satoshi" uniqKey="Komasa S" first="Satoshi" last="Komasa">Satoshi Komasa</name><name sortKey="Okazaki, Joji" sort="Okazaki, Joji" uniqKey="Okazaki J" first="Joji" last="Okazaki">Joji Okazaki</name><name sortKey="Sekino, Tohru" sort="Sekino, Tohru" uniqKey="Sekino T" first="Tohru" last="Sekino">Tohru Sekino</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Honghao" sort="Zhang, Honghao" uniqKey="Zhang H" first="Honghao" last="Zhang">Honghao Zhang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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